2% Vegan PDRN
Helps skin look smoother, more hydrated and renewed. No salmon DNA.
45%reduction in the surface area of deep wrinkles
23%reduction in wrinkle volume
20%reduction in wrinkle depth
*based on published clinical research evaluating Matrixyl® 3000 over 56 days.
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LA Magazine, 2026
“NUTRL Skin is a smart, streamlined skincare system that brings together effective formulas, purposeful ingredients and an easy-to-follow routine designed for everyday consistency.”
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2% Vegan PDRN
Home › Skincare › PDRN Barrier Renewal Mist
K-beauty inspired · made vegan
PDRN Barrier Renewal Mist
The K-beauty ingredient everyone's talking about, made vegan. 2% PDRN with ectoin and niacinamide in a weightless mist that hydrates, calms the look of redness and supports a stronger-looking skin barrier.
- 2% vegan PDRN, no salmon DNA
- Ectoin + niacinamide for barrier support and calmer-looking skin
- Refines the look of pores and texture
- Mist on anytime: after cleansing, over makeup, midday
Recommended for
DehydrationVisible rednessDullnessLook of poresAll skin types
Formulated without
Salmon DNAParabensSiliconesGlutenAnimal testing
One-Time Purchase
$64.00
Membership –
No contract, cancel with ease
1
60 days to love it, or your money back.
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Free Gift + Free Shipping for all domestic orders with membership
Cruelty-freeParaben-freeSilicone-freeGluten-freeGender-neutral
- Hero ingredients: 2% vegan PDRN, ectoin, niacinamide
- Weightless mist for all skin types
- Provides lightweight hydration
- Supports skin renewal
- Helps strengthen the moisture barrier
- Brightens dull, uneven-looking skin
- Calms visible redness
- Improves the appearance of texture and pores
Membership ships every 30, 45 or 60 days ($46, $50 or $54) with a free gift and free shipping. No contract. Pause, adjust frequency, or cancel anytime. Every order is covered: 60 days to love it, or your money back.
What is PDRN?
PDRN, decoded.
Polydeoxyribonucleotide
PDRN (polydeoxyribonucleotide) is a skincare ingredient made of DNA fragments. It became famous in Korean clinics, where it's traditionally sourced from salmon. Ours is vegan PDRN, formulated at 2% and sprayed on in a fine mist.
Salmon PDRN skincare
In-clinic PDRN
NUTRL PDRN Mist
Source
Salmon DNA
Salmon DNA
Vegan
How you use it
Serum
Injection
Mist, at home
Strength shown
Often not stated
Varies
2%
Key ingredients
Three ingredients, one fine mist.
Ectoin
A molecule some microorganisms make to survive harsh conditions. On skin, it holds onto water and helps the moisture barrier. In clinical studies, ectoin creams improved dryness and barrier function.1
Niacinamide
Vitamin B3. It helps skin make its own barrier fats, and studies show it can refine the look of pores and calm the look of redness and uneven tone.2
When to use it
Mist on, anytime.
Step 1.5
After cleansing
Mist before serum to add a layer of hydration.
AM prep
Before makeup
Preps skin so makeup sits smoother.
Refresh
Midday
Refresh dry or tight-feeling skin, even over makeup.
Travel-ready
On the go
Flights, the gym, after shaving.
60 days to love it, or your money back.
What to expect
From first mist to weeks 4+.
First mist
Skin feels instantly refreshed and hydrated.
Weeks 1–2
Skin feels more comfortable and looks calmer.
Weeks 4+
Smoother-looking texture and a more even, balanced look.
How to use
Shake, mist, press in.
01
Shake gently.
Hold 6–8 inches from your face, eyes closed.
02
Mist 2–3 times.
Let it absorb or press in with your palms.
03
Morning, night & anytime.
Refresh whenever your skin needs it.
Questions, answered
You might be thinking…
Vegan sourcing, mist vs. serum, sensitive skin. Here's the straight answer.
Traditionally, yes. Ours is vegan, so there's no salmon DNA in the bottle.
This isn't a water spray. It's a 2% PDRN formula with ectoin and niacinamide, two ingredients with clinical research behind them for hydration and barrier support.
A mist gives you a lightweight layer you can reapply all day, including over makeup. Use it before your serum, not instead of it.
It's formulated for all skin types, and ectoin and niacinamide are known for being gentle. If your skin is reactive, patch test first.
No topical product works like an injection. This is a daily mist that supports hydrated, healthy-looking skin at home.
Reviews
Rated by real customers.
★★★★★4.8/5from 201 reviews
Better together
Add it to your routine.
Mist after the Daily Exfoliating Cleanser, before the Vitamin C Serum, for an extra layer of hydration.
You are here
Step 1.5PDRN Barrier Renewal Mist
Complete the routine
Get all four steps in The Total Package
Daily Exfoliating Cleanser, Purifying Vitamin C Serum, Anti-Aging Under Eye Serum and Restoring Moisturizer, in one routine.
One-time$198
Membership$98
- Kauth M, Trusova OV. Topical Ectoine Application in Children and Adults. Dermatol Ther. 2022. Systematic review, 6 studies.
- Niacinamide clinical research summary, Practical Dermatology.
These statements describe cosmetic effects and are not intended to diagnose, treat, cure or prevent any disease.
PDRN Barrier Renewal Mist
